Shaping Sepsis Care is a new Australian study that brings together patients, carers, and healthcare professionals to identify and rank the most important unanswered research questions about sepsis. 


Led by the National Clinical Care Research (NCCR) Collaboration, it is part of a new Priority Setting Partnership in conjunction with the UK’s James Lind Alliance (JLA).

The aim of Shaping Sepsis Care is to highlight research that could significantly improve sepsis treatment and patient outcomes.

The study will use surveys to determine a Top 10 list of key research priorities in sepsis care and inform the development of the Australian Sepsis Research Roadmap – a guide for researchers and funders to focus on the most impactful studies.

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OBJECTIVES

1

Engage broadly with diverse and representative people and organisations from Australia to identify uncertainties about the recognition, diagnosis, treatment and care of patients with sepsis.

2

Work with former patients and carers who are residing in the community, including those engaged in consumer groups to identify uncertainties about the recognition, diagnosis, treatment and care of patients with sepsis.

3

Identify how to improve care, support and long-term outcomes post sepsis.

4

Define a prioritised list of uncertainties to target for future research via consensus of the priority setting partnership.

5

Use the prioritised list to advocate for research funding, influence policy-makers to publicise the results of Shaping Sepsis Care.

6

Create an Australian Sepsis Research Road Map and inform the work of the National Critical Care Research Collaboration.


 

CLINICAL LEADS

Kimberley Haines

Kimberley Haines is a mid-career researcher and is an Associate Professor in the Department of Critical Care, School of Medicine, at The University of Melbourne. A/Prof Haines is also the Physiotherapy Research Lead and Senior Critical Care Physiotherapist at Western Health, Melbourne, Victoria.

Kimberley is currently undertaking her NHMRC Investigator Grant, to continue her post-doctoral research in ICU recovery. A/Prof Haines is an emerging national and international leader in the field of critical care survivorship and health services research – with particular expertise in consumer engagement, co-design, and qualitative methods in vulnerable cohorts.

Alex Poole

Alex is the program manager of NCCR at the Australian and New Zealand Intensive Care Research Centre at Monash University

Alex holds a PhD from the school of medicine at Adelaide University. He has been a Research and Project Manager of critical care research projects and programs with studies published in high impact journals. Alex also has a keen interest in translating research in to practice and has worked in evidence synthesis with the National Clinical Evidence Taskforce

Manoj Saxena

Manoj is a senior intensive care physician (St. George Hospital, Sydney) and a senior lecturer (The George Institute for Global Health, UNSW).

Manoj’s research interest is in large-scale clinical trials that provide robust and reliable patient-centred evidence on thermoregulation and circulatory management in patients with acute serious illness requiring invasive organ support. He has completed a PhD and NHMRC Early Career fellowship on Thermoregulation for Acute Critical illness, including sepsis and acute brain injury.


STEERING GROUP

In line with JLA principles, the Steering Group includes representations from:

 

PATIENT AND CARER REPRESENTATIVES

  • Adult patients

  • Carers

  • Clinicians

  • Researchers (including First Nations People)

 
  • Dr Jacob Dye is a survivor of sepsis and a Senior Research Fellow at The George Institute. After going into septic shock in 2023, and spending weeks in the ICU, Jacob began to research the psychological outcomes of sepsis.

  • 66-year-old with 46 years' experience working at the Florey Neuroscience Institute. Single father of 23 and 21 year-old daughters and live in Melbourne outer east. Survived severe septic shock after being placed on ECMO 14 years ago. Complete recovery and I am still working full time. Member of several Sepsis support groups and a passionate supporter of medical research.

  • Mary lost her son Preston James to sepsis 22 years ago when he was just two and a half. She established the Preston James Fund with the Mater Foundation, supporting significant advancements in respiratory research. Since 2019, Mary has advocated for sepsis awareness and treatment. She serves on the Queensland Sepsis Steering Committee and chairs the George Institute for Global Health’s Consumer and Community Advisory Committee.

    Professionally, she is a communication strategist and director of STEELE Comms & Engagement, consulting to Sepsis Australia since February 2024.

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  • A Sepsis survivor with Post Sepsis Syndrome. Lynda has been a consumer advocate in the public and private health sectors for 20 years, and involved in research for 10 years. She was appointed by the Health Minister to the Aged Care Council of Elders in December 2023.

 

CLINICAL REPRESENTATIVES

  • Simon is a Professor of Critical Care in Sydney, a founding member and is a past-Chair of the Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group, past chair of the International Sepsis Forum, and past Vice President of the Global Sepsis Alliance. He is the Director of Sepsis Australia and the Asia Pacific Sepsis Alliance.

  • Kimberley Haines is a mid-career researcher and is an Associate Professor in the Department of Critical Care, School of Medicine, at The University of Melbourne. A/Prof Haines is also the Physiotherapy Research Lead and Senior Critical Care Physiotherapist at Western Health, Melbourne, Victoria. Kimberley is currently undertaking her NHMRC Investigator Grant, to continue her post-doctoral research in ICU recovery.

    A/Prof Haines is an emerging national and international leader in the field of critical care survivorship and health services research – with particular expertise in consumer engagement, co-design, and qualitative methods in vulnerable cohorts.

  • Associate Professor Naomi Hammond is an intensive care nurse researcher. She works part-time as the Critical Care and Sepsis Australia Program Head at The George Institute for Global Health and part-time as the Executive Director, Research for the Northern Sydney Local Health District.

    Naomi holds several other appointments including NHMRC Emerging Leader Fellow; Conjoint Associate Professor at the Faculty of Medicine, University of New South Wales; Treasurer of the Asia Pacific Sepsis Alliance, and Chair of the Australian Critical Care Nurses Research Advisory Panel.

  • Professor Yugeesh Lankadeva is a NHMRC Emerging Leader Fellow and a National Heart Foundation Future-Leader Fellow and leads the Critical Care Research Department at the Florey Institute of Neuroscience and Mental Health. His research aims to understand the pathophysiology of sepsis. Armed with this knowledge, he hopes to develop novel diagnostics and therapeutics to improve patient-centered health outcomes.

  • Dr Stephen Macdonald is an Emergency Physician based in Western Australia. He has a research interest in acute sepsis care which was the subject of his PhD awarded in 2018. He remains actively engaged in sepsis research including co-leading a major multi centre randomised trial of resuscitation strategies in septic shock. He has been involved in a number of sepsis advocacy and policy areas over the past decade. In 2019 he was awarded a Churchill Fellowship to study best practice approaches to sepsis care in the USA, Canada and United Kingdom.

  • Melissa McDonnell is a proud Kamilaroi woman, is a dedicated researcher in the Guunu-maana (Heal) Aboriginal and Torres Strait Islander Health Program at The George Institute for Global Health. With over 30 years of experience in Aboriginal health, Melissa has been a relentless advocate for equity and transformative change for Aboriginal people and communities. She brings invaluable lived experience of the systemic disparities affecting Aboriginal people. These experiences have shaped her passionate commitment to driving meaningful, long-term improvements in health outcomes for Aboriginal and Torres Strait Islander communities through innovative, sustainable, and culturally grounded research.

  • Alex is the program manager of NCCR at the Australian and New Zealand Intensive Care Research Centre at Monash University

    Alex holds a PhD from the school of medicine at Adelaide University. He has been a Research and Project Manager of critical care research projects and programs with studies published in high impact journals. Alex also has a keen interest in translating research in to practice and has worked in evidence synthesis with National Clinical Evidence Taskforce

  • Manoj is a senior intensive care physician (St. George Hospital, Sydney) and a senior lecturer (The George Institute for Global Health, UNSW).

    Manoj’s research interest is in large-scale clinical trials that provide robust and reliable patient-centred evidence on thermoregulation and circulatory management in patients with acute serious illness requiring invasive organ support. He has completed a PhD and NHMRC Early Career fellowship on Thermoregulation for Acute Critical illness, including sepsis and acute brain injury.

  • Dr Paul Secombe is a senior intensivist based at the Queen Elizabeth Hospital in Adelaide, South Australia. He spent more than a decade working in the intensive care unit of the Alice Springs Hospital, a unit which sees a disproportionate amount of sepsis. He is a PhD candidate within the the School of Public Health and Preventive Medicine at Monash University, and is awaiting the outcome of his thesis examination.

    He is also the clinical lead for the ANZICS CORE Adult Patient Database, and a member of the ANZICS National Outlier Management Committee.

  • Dr Kelly Thompson is a National Health and Medical Research Council of Australia, Emerging Leadership Fellow at The George Institute for Global Health. Concurrently she is Director of Research Operations at Nepean Blue Mountains Local Health District.

    She holds a Doctor of Philosophy and Master of Public Health from the School of Population Health, Faculty of Medicine, UNSW, Sydney. She is a Registered Nurse, with clinical experience in intensive care.

    Kelly’s primary research interest is in health and gender equity in the clinical area of infection and sepsis. She uses population level data to understand and improve equity in health outcomes for survivors of sepsis and critical illness.

  • Andrew is Head of Research at The Alfred ICU, Melbourne VIC, and Deputy Director, Australian and New Zealand Intensive Care Research Centre - Monash University.

    His research interests include sepsis, traumatic brain injury, neurocritical care, and extra-corporeal membrane oxygenation. He is passionate about supporting trainees/early-career clinician-scientists, and increasing diversity in clinical research. Andrew is Vice-Chair of the Australian and New Zealand Intensive Care Society (ANZICS) - Clinical Trials Group (CTG), and is a proud product of Aotearoa New Zealand.

  • Li has been working as an intensive care doctor for 8 years in China and 11 years in Australia before he became a General practitioner at Hawthorn East Medical & Aesthetic Clinic. He has special interest in acute renal failure in sepsis, and septic shock, and published more than forty papers in this area.

 

PROJECT TEAM

JLA CONSULTANT & STEERING GROUP CHAIR

  • Jonathan has been a JLA Adviser since April 2019, and supports several JLA Priority Setting Partnerships. After spending many years as a biomedical researcher, Jonathan moved into research management and has worked in Research Council, University and NHS settings. He joined the NIHR Clinical Research Network in 2007, holding a number of different roles encompassing 26 different clinical specialties over a period of 12 years. With over 25 years of experience networking with charities, the public and private sectors, Jonathan is passionate about improving the access of patients, their carers and the public to research which makes a real impact on people’s lives.

  • Rose worked with the Australian New Zealand Consortium in Paediatric Oncofertility (ANZCO) guidelines group. She also worked as Administration Officer for the Monash University Clinical Trial Centre (MUCTC).

    Rose has experience coordinating primary endpoints for the ASPirin in Reducing Events in the Elderly (ASPREE XT) trial and holds a First-Class Honours in the field of Cardiovascular Pharmacology at Monash University. She studied a Bachelor of Pharmacy at Heinrich Heine University, Germany.

  • Eloise is an executive generalist, a consultant with more than 25 years experience in high-profile, multi-national and not-for-profit organisations in various strategic communications, stakeholder engagement, public relations and project management roles. She has experience both in-house and agency with a unique understanding of a number of industries; including health, sport, publishing, government, education, property and automotive.

    She has worked on several recent projects within the School of Public Health & Preventive Medicine at Monash University including the National COVID-19 Clinical Evidence Taskforce and SPHERE.

  • Simon is a strategist/designer/illustrator and consultant who specialises in visualising information, concepts, space and data. Often these pieces require broader strategic design to find their audience and be useful. This practise employs strategy, symbolism and codification to make simple informative accessible (mainly digital) experiences

  • Dr Kristina Staley is Director of TwoCan Associates, a small consultancy specialising in promoting and supporting patient and carer involvement in health and social care research. Over the last 25 years she has worked with a wide range of organisations in the voluntary and statutory sector to develop policy and practice, and to evaluate the impact of involvement. She has worked with more than 30 James Lind Alliance Priority Setting Partnerships as an information specialist and carried out one of the first evaluations of the impact of Priority Setting Partnerships.

 

 PARTNERS

 Frequently asked questions

    • People who have had sepsis 

    • Carers of people who have had sepsis (families, partners, friends etc.) 

    • Health care professionals involved in the care/treatment of patients with sepsis

    Please note: Survey respondents must be over 18 .

  • It should take about 10 minutes to complete

  • The survey will be available online and accessible via this website or a direct URL that will take you to Qualtrix where the survey is hosted.

    It will also be available in print format, either downloaded from this page or we can mail to you. The survey can then be returned free via replay mail.

    This page will be updated with details once the survey goes live (expected March 2025).

  • There will be two surveys.

    Survey 1 offers sepsis patients, carers and healthcare professionals the chance to participate in a survey aimed at gathering their questions and concerns about sepsis. This input will help us identify the most common unanswered research questions. Their questions can help us find important areas to research in order to improve the healthcare and wellbeing of Australians affected by Sepsis.

    Once we collect the questions, we will review them against existing published research to determine which have already been addressed.

    From here we conduct Survey 2 to help prioritise the summary questions.

    Ultimately, we will publish a final list of the Top 10 unanswered research questions, encouraging researchers and funding bodies to focus on the most urgent and relevant needs of those affected by Sepsis.

  • Your question(s) will be gathered together and examined with questions we receive from everyone else who takes part in this survey.

    The questions that haven’t already been answered by research will be published (see below for more information). 

    They will go through a process of prioritisation which you can also be involved in if you like.

    This will result in a ‘top 10’ list of research topics which we will use to influence future research priorities and decisions.

  • We are asking these questions to help us better understand the diverse experiences of the survey participants affected by sepsis across Australia. Your responses will help ensure we are hearing from a wide range of voices. Please note, these questions are optional, and you are welcome to skip any that you would prefer not to answer.

  • Sepsis is a life-threatening infection that frequently requires ICU admission, and still carries significant morbidity and mortality. If not recognised and treated promptly sepsis can result in avoidable death and disability. Sepsis can affect previously healthy people, and has profound impacts on individuals, their families, and the healthcare system. Many sepsis survivors endure substantial morbidity, including amputations, irreversible functional disabilities, persistent symptomatic organ dysfunction, and psychological trauma, often leading to frequent re-hospitalisations.

  • The aim of PSPs is to bring patients, carers and clinicians together to jointly identify priorities for research. The James Lind Alliance's current portfolio of PSPs is on the JLA website. JLA PSPs are characterised by following an evidence-based method set out in the JLA Guidebook and are facilitated by one of a small team of approved JLA Advisers.


    PSPs' objectives are to:

    • bring patients, carers and clinicians together to identify uncertainties or unanswered questions for specific health issues

    • agree by consensus a prioritised 'Top 10' list of those uncertainties for research

    • publicise the methods and results of the PSP

    • draw the results to the attention of research funders, independently of the JLA.

    Advocates of, and individuals from, the following groups are eligible to take part in a PSP:

    • people with experience of the health area in question

    • carers and families of those affected

    • health and social care professionals working with patients and carers in the health area in question.

  • The James Lind Alliance (JLA) is a non-profit making initiative which is funded by the UK’s National Institute of Health Research (NIHR). It provides a “tried-and-tested”, fair and rigorous process to help patients, carers and clinicians work together to agree which are the most important treatment uncertainties affecting their particular interest (in this case sepsis), in order to influence the prioritisation of future research in that area.

  • We’d love your help once the survey is live!

    There will be several options:

    • You can simply forward the survey link or QR code

      OR

    • download and print the survey here and return with free reply paid mail.

  • Please email the project team at contact@nccr.au if you have any further questions.

RESOURCES

We’d love your help to share the survey far and wide. We’re creating these downloadable promotional assets for your use and will update once the survey is live. Please let us know if you need any other formats or have other ideas for materials.

*Coming soon

 

Survey QR code

Shaping Sepsis Care Survey 1 QR code


Website QR code

 

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The National Critical Care Research Collaboration acknowledges the assistance of the UK’s Sepsis Priority Setting Partnership team and their generous knowledge sharing and advice from their experience in developing the UK’s top 10 research priorities for sepsis.